Evidence of correlations between mast-cell histamine and beta-endorphin (ir) from NIL-pituitary in the homeostasis

This study was designed to characterize physiological events related to a single or repeated experimental anaphylactoid reactions (by Compound 48/80) in non-stressed or cold-restrained rats. Acute treatment with Compound 48/80 (1 mg/kg, i.p.) increases Beta-endorphin(ir) content in the neurointermediate lobe (NIL) of rat pituitary. Moreover, repeated treatment with Compound 48/80 showed tolerance effects. These animals, exposed to stressful conditions, exhibited a fully evident paw oedema following carrageenin oedema-test, whereas saline-pretreated rats, under the same experimental conditions, showed reduced local inflammation. Since Compound 48/80 produces characteristic, systemic, anaphylactoid reaction in the rat, with a very high degree of selectivity in its action, our results suggest that mast-cell histamine and Beta-endorphin from NIL pituitary are involved in the body's reactivity to stressful stimuli.