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Platelets in preeclamptic pregnancies fail to exhibit the decrease in mitochondrial oxygen consumption rate seen in

Andrew M Malinow1,2, Rosemary A Schuh3, Omar Alyamani3

  • 1Department of Anesthesiology, University of Maryland School of Medicine, S11D15-UMMC, 22 S. Greene St, Baltimore, MD 21201, U.S.A. amalinow@som.umaryland.edu.

Bioscience Reports
|April 15, 2018
PubMed
Summary
This summary is machine-generated.

Platelets from preeclamptic pregnancies show altered mitochondrial function, with reduced glucose metabolism. Healthy pregnancies exhibit reduced platelet respiration before 34 weeks, a mechanism potentially reversed in preeclampsia.

Keywords:
mitichondriaplateletspreeclampsiapregnancy

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Area of Science:

  • Obstetrics and Gynecology
  • Mitochondrial Biology
  • Biomarker Discovery

Background:

  • Preeclampsia is a serious pregnancy complication.
  • Platelet metabolic changes may serve as biomarkers for systemic bioenergetic alterations.
  • Mitochondrial dysfunction is implicated in various disease states.

Purpose of the Study:

  • To investigate functional alterations in platelet mitochondria during preeclampsia.
  • To test the hypothesis that platelet mitochondria display functional changes in preeclampsia.
  • To identify potential platelet-based biomarkers for preeclampsia.

Main Methods:

  • Platelets were collected from pregnant women (healthy and preeclamptic) and non-pregnant women.
  • Seahorse respirometry was used to measure oxygen consumption (OCR) and extracellular acidification (ECAR) rates.
  • Analysis included basal respiration, maximal respiratory capacity, and mitochondrial efficiency (RCR).

Main Results:

  • Maximal respiratory capacity was 37% lower in healthy pregnant platelets compared to preeclamptic.
  • Basal extracellular acidification rate was reduced in preeclamptic pregnancies.
  • Mitochondrial efficiency (RCR) was lower in healthy pregnant women compared to non-pregnant women.
  • Normal pregnancy showed reduced platelet respiration before 34 weeks' EGA, which normalized later.

Conclusions:

  • Preeclampsia is associated with altered platelet mitochondrial function, including changes in respiration and metabolism.
  • A normal pregnancy mechanism of reduced platelet mitochondrial respiration may be reversed or lost in preeclampsia.
  • Platelet mitochondrial function could serve as a biomarker for preeclampsia and its progression.