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Confocal scanning laser microscopy in patients with postoperative endophthalmitis
T Fiore1, G Torroni1, B Iaccheri1
1Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy.
International Ophthalmology
|April 15, 2018
Summary
Postoperative endophthalmitis can cause subclinical inflammation in the posterior cornea, detected by in vivo confocal microscopy. This study found increased keratocyte activation and unique deposits in treated eyes, indicating chronic corneal changes.
Area of Science:
- Ophthalmology
- Corneal Science
- Microscopy
Background:
- Postoperative endophthalmitis is a serious complication following intraocular surgery.
- Understanding long-term corneal changes after endophthalmitis is crucial for patient management.
Purpose of the Study:
- To investigate corneal layer alterations in eyes treated for acute postoperative endophthalmitis using in vivo confocal microscopy (IVCM).
Main Methods:
- Retrospective comparison of eyes treated for post-cataract endophthalmitis (n=12) with control groups (uneventful cataract surgery, n=12; uneventful vitrectomy, n=12).
- Corneal analysis via laser scanning IVCM after a minimum 8-month follow-up.
- Evaluation of corneal epithelial cells, nerve fibers, keratocytes, and endothelium.
Main Results:
- No significant differences in corneal epithelial or endothelial cell density, nerve fiber density, or anterior keratocyte activation between groups.
- Significantly higher posterior keratocyte activation in the endophthalmitis group (p<0.01).
- Presence of Langerhans cells and dendritic-shaped endothelial deposits in the endophthalmitis group, absent in controls (p<0.01).
Conclusions:
- IVCM effectively detects subclinical chronic corneal abnormalities post-endophthalmitis.
- Findings suggest localized chronic inflammation in the posterior stroma related to the infectious process.
- Further research is needed to elucidate acute-phase pathological processes.
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