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The physical and cellular conditions of the human pulmonary circulation enable thrombopoiesis

Yasmine Ouzegdouh1, Claude Capron2, Thomas Bauer3

  • 1Département d'Immuno-Hématologie, Inserm U. 1016, Institut Cochin, Paris, France.

Experimental Hematology
|April 15, 2018
PubMed

Insights

Platelet production may occur in the lungs, as megakaryocytes (MKs) were found in human pulmonary circulation. The lung

Area of Science:

  • Hematology
  • Pulmonary Medicine
  • Vascular Biology

Background:

  • Growing animal evidence suggests platelet production in the lungs.
  • The precise mechanisms and human relevance of pulmonary platelet production remain unclear.

Purpose of the Study:

  • To investigate evidence for pulmonary platelet production in human conditions.
  • To analyze the role of the pulmonary vascular microenvironment on megakaryocyte (MK) function and platelet release.

Main Methods:

  • Documented the presence of megakaryocytes (MKs) in human pulmonary circulation.
  • Analyzed the influence of the vascular microenvironment on MK function.
  • Investigated factors influencing platelet formation and release from MKs.

Main Results:

  • Confirmed the presence of MKs within the human pulmonary circulation.
  • The endothelial microenvironment was found to favor platelet formation.
  • Von Willebrand factor and physical forces in flowing blood are critical for platelet release.
  • Demonstrated that circulating MKs can alter their ploidy.

Conclusions:

  • The human pulmonary circulation provides a microenvironment conducive to platelet production.
  • Pulmonary platelet production represents a novel pathophysiological pathway.
  • Identified potential new targets for therapeutic interventions in platelet disorders.

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