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Effect of rapid sodium load on circulating atrial natriuretic polypeptide
The American Journal of Physiology
|April 1, 1988
Summary
A rapid increase in plasma sodium concentration (PNa) does not elevate circulating atrial natriuretic polypeptide (ANP) levels in dogs. This suggests ANP is not involved in regulating plasma sodium concentration.
Area of Science:
- Nephrology
- Endocrinology
- Cardiovascular Physiology
Background:
- Atrial natriuretic polypeptide (ANP) plays a role in regulating body fluid homeostasis.
- The relationship between plasma sodium concentration (PNa) and ANP secretion is not fully understood.
Purpose of the Study:
- To investigate whether a rapid increase in PNa stimulates ANP release in conscious dogs.
- To determine if ANP contributes to the regulation of plasma sodium concentration.
Main Methods:
- Conscious dogs received intravenous injections of hypertonic NaCl solution to rapidly elevate PNa.
- Plasma sodium concentration, ANP levels, and urinary sodium and water excretion were measured.
- Analyses included corrections for hemodilution.
Main Results:
- Rapid increases in PNa were achieved without significant changes in plasma ANP levels.
- Urinary sodium and water excretion increased, and plasma vasopressin levels rose.
- Even with larger PNa increases, ANP levels remained unchanged.
Conclusions:
- A rapid, physiological increase in PNa does not stimulate ANP secretion.
- These findings suggest that ANP does not play a significant role in the short-term regulation of plasma sodium concentration.