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Macrophages: The Road Less Traveled, Changing Anticancer Therapy
1Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
Trends in Molecular Medicine
|April 16, 2018
Summary
Targeting macrophages, key immune cells in cancer, shows promise for anticancer therapy. However, limited clinical success highlights the need to better understand macrophage diversity for novel therapeutic opportunities.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- Macrophages are versatile immune cells found in all vertebrate tissues.
- They play critical roles in development, tissue homeostasis, and disease, including cancer.
- Macrophages are a significant component of the tumor microenvironment, influencing tumorigenesis and metastasis.
Purpose of the Study:
- To review the potential of targeting macrophages for anticancer therapy.
- To highlight knowledge gaps concerning macrophage ontogeny, regulation, and tissue-specific diversity.
- To explore how understanding macrophage subsets could lead to new therapeutic strategies.
Main Methods:
- Literature review of preclinical and clinical studies on macrophage-targeted anticancer therapies.
- Analysis of current understanding of macrophage biology in the context of cancer.
- Discussion of challenges and future directions in the field.
Main Results:
- Preclinical strategies targeting macrophages show promise and are entering clinical trials.
- Clinical success of these strategies has been limited to date.
- Significant gaps remain in understanding macrophage ontogeny, regulation, and tissue-specific functions.
Conclusions:
- Targeting macrophages offers a promising avenue for enhancing current anticancer therapies.
- Further research into the diverse subsets of macrophages is crucial.
- Identifying tissue-specific macrophage characteristics may unlock novel therapeutic opportunities in oncology.
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