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Hypertrophic Cardiomyopathy: Clinical Update

Jeffrey B Geske1, Steve R Ommen1, Bernard J Gersh1

  • 1Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.

JACC. Heart Failure
|April 16, 2018
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is a common genetic heart condition. This clinical update covers diagnosis, risk stratification, and management for HCM patients.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most common inherited heart muscle disease.
  • It is characterized by left ventricular hypertrophy without secondary causes.
  • Genetic mutations in sarcomeric proteins are primary drivers, though often unidentified.

Purpose of the Study:

  • To provide a clinical update on hypertrophic cardiomyopathy.
  • To cover diagnosis, family screening, imaging, risk stratification, and symptom management.
  • To address the challenges in managing this diverse condition.

Main Methods:

  • Review of current clinical practices and literature.
  • Focus on diagnostic criteria and imaging techniques.
  • Emphasis on risk stratification and therapeutic strategies.

Main Results:

  • HCM presents with diverse phenotypes, from asymptomatic to severe heart failure or sudden cardiac death.
  • Most patients develop dynamic left ventricular outflow obstruction.
  • Risk stratification for sudden cardiac death remains a significant clinical challenge.

Conclusions:

  • Effective management of HCM involves addressing dynamic obstruction through various interventions.
  • Early diagnosis and family screening are crucial for heritable conditions.
  • This update aims to guide clinicians in optimizing patient care for HCM.

Keywords:
CMRechocardiographygeneticshypertrophic cardiomyopathysudden death

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