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Hypertrophic Cardiomyopathy: Clinical Update.
Jeffrey B Geske1, Steve R Ommen1, Bernard J Gersh1
1Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
JACC. Heart Failure
|April 16, 2018
Summary
Hypertrophic cardiomyopathy (HCM) is a common genetic heart condition. This clinical update covers diagnosis, risk stratification, and management for HCM patients.
Area of Science:
- Cardiology
- Genetics
- Internal Medicine
Background:
- Hypertrophic cardiomyopathy (HCM) is the most common inherited heart muscle disease.
- It is characterized by left ventricular hypertrophy without secondary causes.
- Genetic mutations in sarcomeric proteins are primary drivers, though often unidentified.
Purpose of the Study:
- To provide a clinical update on hypertrophic cardiomyopathy.
- To cover diagnosis, family screening, imaging, risk stratification, and symptom management.
- To address the challenges in managing this diverse condition.
Main Methods:
- Review of current clinical practices and literature.
- Focus on diagnostic criteria and imaging techniques.
- Emphasis on risk stratification and therapeutic strategies.
Main Results:
- HCM presents with diverse phenotypes, from asymptomatic to severe heart failure or sudden cardiac death.
- Most patients develop dynamic left ventricular outflow obstruction.
- Risk stratification for sudden cardiac death remains a significant clinical challenge.
Conclusions:
- Effective management of HCM involves addressing dynamic obstruction through various interventions.
- Early diagnosis and family screening are crucial for heritable conditions.
- This update aims to guide clinicians in optimizing patient care for HCM.
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