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Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based

Takashi Hisamatsu1, Katsuyuki Miura2, Akira Fujiyoshi3

  • 1Department of Environmental Medicine and Public Health, Faculty of Medicine, Shimane University, Izumo, Japan; Department of Public Health, Shiga University of Medical Science, Otsu, Japan; Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.

Atherosclerosis
|April 16, 2018
PubMed

Insights

Serum magnesium levels are linked to a lower risk of aortic valve calcification, while higher phosphorus levels are associated with increased risk. These micronutrients may help predict or prevent calcific aortic valve disease.

Area of Science:

  • Cardiovascular Medicine
  • Nutritional Science
  • Radiology

Background:

  • Calcific aortic valve disease (CAVD) is a prevalent condition, yet the role of micronutrients in its development is not well understood.
  • Aortic valve calcification (AVC) is a key feature of CAVD, impacting cardiovascular health.
  • Evaluating the association between serum micronutrient levels and AVC is crucial for understanding CAVD pathogenesis.

Purpose of the Study:

  • To investigate the relationship between serum magnesium, phosphorus, and calcium levels and the prevalence, incidence, and progression of aortic valve calcification (AVC).
  • To determine if these micronutrients can serve as potential biomarkers for CAVD risk prediction or prevention.

Main Methods:

  • A prospective study was conducted on a population-based sample of Japanese men aged 40-79 years.
  • Participants were free of known cardiovascular disease and chronic kidney disease at baseline.
  • Aortic valve calcification (AVC) was quantified using serial computed tomography (CT) scans and the Agatston method.

Main Results:

  • Higher serum magnesium levels were associated with a reduced risk of AVC prevalence and incidence (RR: 0.62 for both).
  • Elevated serum phosphorus levels were linked to an increased risk of AVC prevalence and incidence (RR: 1.45 and 1.93, respectively).
  • No significant association was found between serum micronutrient levels and the progression of AVC in participants with existing calcification.

Conclusions:

  • Serum magnesium shows an inverse association, while serum phosphorus demonstrates a positive association with AVC prevalence and incidence.
  • These findings suggest that serum magnesium and phosphorus may be valuable in predicting or preventing CAVD.
  • Further research is warranted to confirm these associations and explore potential therapeutic interventions.
Abstract

Keywords:
Aortic valve diseaseCalcificationEpidemiologyMagnesiumPhosphorusProspective study

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