Circulating tumor DNA testing in advanced non-small cell lung cancer
Everett J Moding1, Maximilian Diehn1, Heather A Wakelee2
1Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lung Cancer (Amsterdam, Netherlands)
|April 17, 2018
Summary
Circulating tumor DNA (ctDNA) liquid biopsies offer a non-invasive method to detect mutations in advanced non-small cell lung cancer (NSCLC). These tests help predict treatment response and monitor disease progression.
Area of Science:
- Oncology
- Molecular Diagnostics
Background:
- Circulating tumor DNA (ctDNA) is shed by cancer cells into the blood.
- ctDNA analysis allows for non-invasive detection of tumor-specific mutations.
Purpose of the Study:
- To review the clinical applications of ctDNA testing in advanced non-small cell lung cancer (NSCLC).
- To discuss the role of ctDNA in guiding targeted therapies and monitoring treatment response and resistance.
Main Methods:
- Review of current literature on ctDNA testing in NSCLC.
- Analysis of ctDNA for tumor genotyping and resistance monitoring.
Main Results:
- ctDNA mutations can predict response to targeted therapies.
- Changes in ctDNA levels can monitor treatment response and detect recurrence.
Conclusions:
- Liquid biopsies using ctDNA are a powerful tool for advanced NSCLC.
- ctDNA testing aids in tumor genotyping, treatment selection, and monitoring for resistance.
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