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Related Experiment Video

Updated: Feb 11, 2026

Using Looming Visual Stimuli to Evaluate Mouse Vision

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex.

Mario Dipoppa¹, Adam Ranson², Michael Krumin²

¹Institute of Neurology, University College London, London WC1N 3BG, UK.

|April 17, 2018

Summary

This summary is machine-generated.

Locomotion

Keywords:

circuit disinhibition inhibition inhibition stabilized network interneurons locomotion neural field model primary visual cortex recurrence surround suppression

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Area of Science:

Neuroscience
Computational Neuroscience
Cortical Circuits

Background:

Cortical computation involves interactions between pyramidal cells and interneurons (Sst, Vip, Pvalb).
Understanding these circuits is crucial for deciphering brain function.

Purpose of the Study:

To investigate the circuit mechanisms underlying neuronal interactions in the mouse primary visual cortex (V1).
To test the validity of a disinhibitory model and a recurrent network model under different conditions.

Main Methods:

In vivo calcium imaging of four neuronal types (pyramidal, Sst, Vip, Pvalb) in mouse V1.
Recording neuronal activity in darkness and during visual stimulation, with and without locomotion.

Main Results:

A disinhibitory model explained locomotion effects in darkness but failed with visual stimuli.
Locomotion modulated Sst and Vip cell responses differently depending on stimulus size.
A recurrent network model, incorporating locomotion-induced changes in synaptic weights, successfully predicted cell activity.

Conclusions:

Locomotion alters cortical circuit dynamics beyond simple disinhibition.
Effective synaptic connectivity, modulated by locomotion, is key to understanding interneuron interactions and cortical computation.