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Advances in transformable drug delivery systems.

Quanyin Hu1, Qian Chen1, Zhen Gu2

  • 1Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Division of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Biomaterials
|April 17, 2018
PubMed
Summary
This summary is machine-generated.

Transformable drug delivery systems (DDSs) offer precise control over drug release and enhanced efficacy. This review details recent advancements in DDSs that change form for targeted biomedical applications.

Keywords:
Cancer therapyDrug deliveryStimuli-responsiveTransformable formulation

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Drug Delivery

Background:

  • Transformable drug delivery systems (DDSs) are emerging as advanced platforms for precision medicine.
  • These systems can alter their physical properties and function at specific disease sites.
  • Their controllability and design flexibility are key to enhanced therapeutic outcomes.

Purpose of the Study:

  • To review recent developments in intracellularly and extracellularly transformable DDSs.
  • To highlight functionalities such as prolonged retention, inhibited endocytosis, and enhanced cytotoxicity.
  • To discuss stimuli-responsive mechanisms triggering DDS transformation.

Main Methods:

  • Review of recent scientific literature on transformable drug delivery systems.
  • Categorization of DDSs based on transformation location (intracellular/extracellular).
  • Analysis of stimuli (pH, enzyme, light, temperature, redox, mechanical force) that trigger DDS transformation.

Main Results:

  • Transformable DDSs demonstrate significant potential in controlling drug release kinetics.
  • Assembly or disassociation of formulation units enables diverse functionalities.
  • Various stimuli effectively trigger the transformation process for targeted drug delivery.

Conclusions:

  • Transformable DDSs represent a promising frontier in precision drug delivery.
  • Further research into stimuli-responsive mechanisms can optimize therapeutic efficacy.
  • Addressing future challenges will be crucial for clinical translation of these advanced DDSs.