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Updated: Feb 11, 2026

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
Published on: June 11, 2019
Current perspectives in Set7 mediated stem cell differentiation
Nazanin Karimnia1, Haloom Rafehi1, Natasha K Tuano1
1Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.
Abstract:
Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.
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