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oncoNcRNA: A Web Portal for Exploring the Non-Coding RNAs with Oncogenic Potentials in Human Cancers

Ze-Lin Wang1,2, Xiao-Qin Zhang3, Hui Zhou1,2

  • 1Key Laboratory of Gene Engineering of the Ministry of Education, GuangZhou 510275, China. wangzl6@mail2.sysu.edu.cn.

Non-Coding RNA
|April 17, 2018
PubMed

Insights

oncoNcRNA is a new web portal that analyzes somatic copy number alterations (SCNAs) in non-coding RNAs (ncRNAs) across 64 cancer types. It helps researchers identify ncRNAs with oncogenic potential, aiding cancer research.

Area of Science:

  • Genomics
  • Cancer Biology
  • Bioinformatics

Background:

  • Non-coding RNAs (ncRNAs) play roles in cancer, but their functions are largely unknown.
  • Somatic copy number alterations (SCNAs) are common in cancer and can affect gene function.

Purpose of the Study:

  • To develop a web portal, oncoNcRNA, for exploring the oncogenic potential of ncRNAs in human cancers.
  • To integrate and analyze SCNA data for a comprehensive catalog of ncRNAs across numerous cancer types.

Main Methods:

  • Integrated large-scale SCNA data from various human cancer types.
  • Developed the oncoNcRNA web portal to characterize SCNAs for over 58,000 lncRNAs, 34,000 piRNAs, 2700 miRNAs, 600 tRNAs, and 400 snoRNAs in 64 cancer types.
  • Created a web-based tool, Correlations, to analyze gene expression and copy number relationships using TCGA data.

Main Results:

  • Identified a large number of ncRNAs frequently amplified or deleted across and within tumor types.
  • oncoNcRNA provides an intuitive platform for analyzing the oncogenic potential of specific ncRNAs.
  • The Correlations tool enables exploration of gene expression and copy number associations in cancer.

Conclusions:

  • oncoNcRNA is a valuable resource for cancer researchers investigating ncRNA function and clinical relevance.
  • The portal facilitates the discovery of novel oncogenic ncRNAs.
  • oncoNcRNA enhances our understanding of the role of ncRNAs in tumorigenesis and progression.
Keywords:
biomarkercancerncRNAssomatic copy number alteration

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