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Updated: Feb 11, 2026
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How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
Published on: August 19, 2020
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Targeted Interventions in Critically Ill Children with Severe Dengue.
Suchitra Ranjit1, Gokul Ramanathan1, Balasubramaniam Ramakrishnan2
1Pediatric Intensive Care Unit, Apollo Children's Hospital, Chennai, Tamil Nadu, India.
Summary
Intensive Care Unit (ICU) interventions improved severe dengue outcomes. This approach reduced fluid overload, abdominal compartment syndrome, and mortality in pediatric patients, offering a new standard of care.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Pediatrics
Background:
- Severe dengue (SD) poses a high mortality risk, even with World Health Organization (WHO) guidelines.
- Treatment complications and disease severity contribute to mortality in severe dengue patients.
Purpose of the Study:
- To evaluate the impact of enhanced Intensive Care Unit (ICU) supportive measures on severe dengue outcomes.
- To compare outcomes of standard therapy (ST) plus ICU interventions (ST+) versus ST alone.
Main Methods:
- A prospective observational study of severe dengue patients receiving enhanced ICU care (ST+).
- Comparison with a matched retrospective cohort receiving standard therapy (ST).
- Interventions included early albumin for refractory shock, monitoring for abdominal compartment syndrome (ACS), and high-risk intubation protocols.
Main Results:
- The ST+ group showed decreased positive fluid balance and less symptomatic ACS requiring drainage (7.7% vs. 30%).
- Reduced intubation and ventilation needs (18.4% vs. 53.3%) were observed in the ST+ group.
- Lower incidence of hemorrhage, acute kidney injury, and significantly reduced pediatric ICU mortality (2.6% vs. 26%) in the ST+ group.
Conclusions:
- Targeted ICU interventions significantly improve outcomes for children with severe dengue and refractory shock.
- Proactive application of ICU supportive measures decreases resuscitation morbidity and mortality in severe dengue.
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