Related Experiment Video
Updated: Feb 11, 2026

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty
Published on: February 27, 2018
Tranexamic acid in total hip arthroplasty: Mixed treatment comparisons of randomized controlled trials and cohort
Kannan Sridharan1, Gowri Sivaramakrishnan2
1Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.
Background:
The present study is a network meta-analysis of various routes of tranexamic acid (TXA) in patients with total hip arthroplasty (THA).
Methods:
Randomized controlled trials and cohort studies evaluating TXA in patients with THA were included. Number of patients requiring blood transfusion was the primary outcome.
Results:
Pooled estimate for TXA use against placebo for blood transfusion rate was 0.30 [0.23, 0.39] favoring TXA. Maximum reduction in the risk of blood transfusion was observed with topical plus intra-operative intravenous TXA.
Conclusion:
Combined topical and intravenous TXA during surgery may perform better than other modes in patients undergoing THA.
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