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Deal a death blow! HCC in cirrhotics - thrombotic complications: their frequency, characteristics, and risk factors

Khalid Mahmood1, Iftikhar Haider Naqvi1, Aamer Mahmood2

  • 1Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

Przeglad Gastroenterologiczny
|April 17, 2018
PubMed

Insights

Hepatocellular carcinoma (HCC) patients with thrombotic complications, primarily tumor thrombosis, face a poorer prognosis. Key risk factors include older age, male gender, larger tumor size, and advanced HCC stage.

Area of Science:

  • Hepatology
  • Oncology
  • Gastroenterology

Background:

  • Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer globally, ranking sixth in incidence.
  • Thrombotic complications, including portal vein tumor thrombosis (PVTT) and bland portal vein thrombosis (PVT), are frequent in HCC patients and associated with poor outcomes.

Purpose of the Study:

  • To analyze demographic, clinical, and biochemical profiles of HCC patients.
  • To compare these parameters between HCC patients with and without thrombotic complications.
  • To identify risk factors associated with thrombotic complications in HCC.

Main Methods:

  • Retrospective, cross-sectional study design.
  • Collection and analysis of clinical and biochemical data from HCC patients.
  • Statistical significance assessed using p-values, with p < 0.05 considered significant.

Main Results:

  • 38.7% of HCC patients (118/305) experienced thrombotic complications.
  • PVTT was observed in 74.5% of cases, while bland PVT occurred in 25.5%.
  • Significant risk factors for thrombosis included advanced age, male gender, larger tumor size, advanced HCC stage (Okuda II, III), multifocal/massive tumor morphology, and presence of complications like ascites and hepatic encephalopathy.

Conclusions:

  • Viral-related HCC is a significant health concern.
  • Thrombotic complications in HCC are predominantly tumor-related rather than bland thrombosis.
  • Advanced age, male gender, larger tumor size, advanced HCC stage, and tumor morphology are critical risk factors for thrombotic complications.
Abstract

Keywords:
cirrhosishepatocellular carcinomatumour thrombosis

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