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Contrast medium-induced transient severe leukopenia.

Takashi Hongo1, Satoshi Nozaki1, Midori Tsuchiya1

  • 1Emergency Department Okayama Saiseikai General Hospital Okayama Japan.

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|April 17, 2018
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Summary

A rare case of contrast media-induced transient leukopenia occurred in a 73-year-old man after a CT scan. Prompt treatment led to rapid white blood cell count recovery and discharge.

Keywords:
AllergyERcomputed tomographycontrast mediadrug‐induced leukopenia

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Area of Science:

  • Radiology
  • Hematology

Background:

  • Contrast media-induced transient leukopenia is an exceptionally rare adverse reaction.
  • A history of allergic reactions to contrast media may be a risk factor.

Observation:

  • A 73-year-old male presented with chest discomfort, fever, and leukopenia (WBC 930/μL) one hour after an abdominal contrast-enhanced computed tomography (CECT).
  • The patient received non-ionic iodinated contrast medium intravenously during the CECT.

Findings:

  • The patient exhibited severe leukopenia with an absolute neutrophilic count of 232/μL.
  • Treatment included intravenous antibiotics, chlorpheniramine maleic acid, famotidine, and methylprednisolone.

Implications:

  • The patient's white blood cell count normalized within 24 hours.
  • This case highlights the importance of recognizing and managing contrast media-induced transient leukopenia, despite its rarity.