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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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Related Experiment Video

Updated: Feb 11, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
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An objective in vivo diagnostic method for inflammatory bowel disease.

Sophie C Payne1,2, Robert K Shepherd1,2, Alicia Sedo3

  • 1Bionics Institute, East Melbourne, Victoria 3002, Australia.

Royal Society Open Science
|April 17, 2018
PubMed
Summary

Real-time electrical impedance measurements in rats show significant decreases in the inflamed intestine. This quantitative method correlates with histological damage, offering a potential new tool for inflammatory bowel disease assessment.

Keywords:
electrical impedanceinflammatory bowel diseasemucosal permeabilityvoltage transient

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Area of Science:

  • Gastroenterology
  • Biomedical Engineering
  • Inflammation Research

Background:

  • Inflammatory bowel disease (IBD) diagnosis relies on invasive and delayed methods like biopsies and endoscopy.
  • Current methods lack real-time quantitative assessment of mucosal barrier function.
  • A need exists for objective, non-invasive, real-time monitoring of IBD severity.

Purpose of the Study:

  • To investigate the correlation between in vivo electrical transmural impedance and histological measures of intestinal inflammation.
  • To assess the utility of electrical impedance as a real-time quantitative assay for inflammatory bowel disease.

Main Methods:

  • Utilized a rat model of IBD induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS).
  • Placed four platinum ball electrodes in the rat small intestine lumen with a subcutaneous return electrode.
  • Measured transmural electrical impedance over 3 hours post-TNBS administration and compared with histological analyses.

Main Results:

  • Intestinal transmural impedance significantly decreased in the TNBS-induced inflamed region compared to control regions (p<0.05).
  • Changes in impedance correlated with histologically assessed mucosal damage.
  • Impedance changes also correlated with increased neutrophil, eosinophil, and T-cell populations in inflamed tissue.

Conclusions:

  • In vivo electrical transmural impedance is a sensitive, quantitative, and real-time indicator of intestinal inflammation in an IBD model.
  • This technique shows promise for objective diagnosis and clinical management of inflammatory bowel disease.
  • Electrical impedance measurements offer a potential non-invasive alternative to current diagnostic procedures.