Primary hyperparathyroidism and Gougerot disease

Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by the overactivation of the parathyroid glands due to the autonomous production of the parathyroid hormone (PTH). The resultant hypercalcemia leads to a myriad of symptoms. Here we report the case of a 54-year-old female with a previous diagnosis of Gougerot disease, in whom clinical (diffuse bone pain, asthenia polydipsia, and polyuria) and laboratory features (calcium level, 3.1 mmol/L; phosphate level, 0.55 mmol/L; alkaline phosphatase level, 70 U/L; and intact PTH level, 1028.9 pmol/L) prompted the diagnosis of PHPT caused by a parathyroid adenoma as confirmed by anatomopathology. After treatment with renal replacement therapy, intravenous fluids and zolendronic acid, and subtotal parathyroidectomy, the patient status improved, with normal laboratory tests. However, the fortuitous nature of the association between Gougerot disease and PHPT as well as the physiopathological links between these two diseases remain to be specified.