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Poly(hydroxybutyrate)/chitosan Aligned Electrospun Scaffold as a Novel Substrate for Nerve Tissue Engineering.

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Aligned poly(3-hydroxybutyrate)/chitosan (PHB/CTS) nanofibers show promise for nerve regeneration. The aligned PHB/CTS 85:15 scaffold demonstrated superior hydrophilicity and tensile strength compared to random scaffolds.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Nerve regeneration presents a significant challenge in therapeutic medicine.
  • Nerve tissue engineering offers innovative solutions for nervous system repair.
  • Nanofibrous scaffolds are crucial for guiding peripheral nerve regeneration.

Purpose of the Study:

  • To fabricate and characterize aligned and random poly(3-hydroxybutyrate)/chitosan (PHB/CTS) nanofibrous scaffolds.
  • To evaluate the potential of these scaffolds for peripheral nerve regeneration applications.

Main Methods:

  • Poly(3-hydroxybutyrate) (PHB) and chitosan (CTS) solutions were prepared in trifluoroacetic acid.
  • Random and aligned PHB/CTS scaffolds were fabricated using electrospinning.
  • Scaffold characteristics including fiber diameter, hydrophilicity, and tensile strength were analyzed.

Main Results:

  • Electrospun PHB/CTS scaffolds exhibited fiber diameters ranging from 675 nm to 870.74 nm.
  • Chitosan addition significantly increased scaffold hydrophilicity, with aligned scaffolds showing enhanced water droplet contact angles.
  • Aligned PHB/CTS 85:15 scaffolds displayed improved tensile strength (8.73 MPa) compared to random counterparts (6.41 MPa).

Conclusions:

  • Aligned PHB/CTS 85:15 nanofibers represent a superior scaffold material for nerve tissue regeneration.
  • The enhanced properties of aligned scaffolds make them ideal for promoting peripheral nerve repair.