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Updated: Feb 11, 2026

Author Spotlight: Radiotherapy and Clonogenic Assays for Advancing Cancer Research and Personalized Medicine
Published on: April 5, 2024
The role of Next-Generation Sequencing in tumoral radiosensitivity prediction
Jean-Emmanuel Bibault1,2, Ingeborg Tinhofer3
1Radiation Oncology Department, Georges Pompidou European Hospital, Assistance Publique - Hôpitaux de Paris, Paris Descartes University, Paris Sorbonne Cité, Paris, France.
Abstract:
Technological advances have led to more precise radiation delivery, which has resulted in significant clinical gains. A better understanding of tumoral radiosensitivity is still needed to develop strategies and further personalize radiation treatments. Next-Generation Sequencing (NGS) and system biology have significantly transformed the field of oncology in the last two decades, but have only a few clinical applications in radiation oncology. This review describes the technical aspects and evolutions of NGS and discusses the latest clinical applications of genomics to predict tumoral radiosensitivity.
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