Related Experiment Video
Updated: Feb 11, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
[Glycogen synthase kinase3 and prostate cancer: An update]
Qing-Ting Hu1, Chang-Bai Liu1, Ben-Yi Li1
1Research Institute of Cell Therapy, People's Hospital of Three Gorges University, Yichang, Hubei 443000, China.
Abstract:
Glycogen synthase kinase3 (GSK3α and GSK3β) are serine/threonine protein kinases acting on numerous substrates and involved in the regulation of various cellular functions such as their proliferation, survival, glycogen metabolism, and autophagy. Accumulating evidence indicates that the expression of GSK3α is increased mainly in androgendependent while that of GSK3β in androgenindependent prostate cancer, and that GSK3β is also involved in the regulation of the transactivation of the androgen receptor (AR) and growth of prostate cancer. Animal experiments have proved that some GSK3 inhibitors, such as lithium, can significantly suppress tumor growth in different animal models of prostate cancer. The GSK3 inhibitor is promising to be an important agent for the clinical management of prostate cancer.
Related Concept Videos
Protein Kinases and Phosphatases
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein Kinases and Phosphatases
ATP Synthase: Structure
ATP Synthase: Mechanism
Receptor Tyrosine Kinases
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

