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[Predictive value of cord blood 25(OH)D3 for early infantile atopic dermatitis]

Min-Min Li1, Chun-Yan Lu, Xiao-Ming Wang

  • 1Department of Pediatrics, Shanghai Fifth People′s Hospital Affiliated to Fudan University, Shanghai 200240, China. liminminfeiyang@126.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|April 17, 2018
PubMed

Insights

Low cord blood vitamin D levels are linked to a higher risk of infantile atopic dermatitis (AD). While associated, vitamin D levels have limited diagnostic power for predicting AD in newborns.

Area of Science:

  • Neonatal Health
  • Dermatology
  • Nutritional Science

Background:

  • Infantile atopic dermatitis (AD) is a common condition with multifactorial causes.
  • Vitamin D status during pregnancy and infancy is increasingly recognized as a potential factor in immune development and allergic diseases.
  • Understanding early predictors of AD can inform preventive strategies.

Purpose of the Study:

  • To investigate the predictive value of cord blood 25-hydroxyvitamin D3 [25(OH)D3] levels for the development of infantile atopic dermatitis (AD).
  • To establish a reference for the primary prevention of early infantile AD based on neonatal vitamin D status.

Main Methods:

  • Enrollment of neonates born during a specific period (July-September 2015).
  • Collection and measurement of cord blood 25(OH)D3 levels at birth.
  • Outpatient follow-up at 6 weeks, 3 months, and 6 months to assess AD incidence.
  • Utilized Receiver Operating Characteristic (ROC) and logistic regression analyses.

Main Results:

  • The incidence of AD was 34% within the first 6 months, with most cases occurring in the first month.
  • Infants who developed AD had significantly lower cord blood 25(OH)D3 levels compared to those without AD (P<0.05).
  • A cord 25(OH)D3 level below 30 nmol/L was associated with a significantly higher incidence of AD (P<0.05).
  • ROC analysis indicated moderate predictive value (AUC=0.648).
  • Low cord 25(OH)D3, maternal seafood preference, family history of atopy, and mixed feeding were identified as risk factors for infantile AD.

Conclusions:

  • Cord blood 25(OH)D3 levels show an inverse association with the risk of developing infantile AD.
  • However, cord blood 25(OH)D3 levels possess limited diagnostic value for predicting infantile AD.
  • Findings suggest potential for vitamin D supplementation as a preventive measure, warranting further investigation.
Abstract

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