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Updated: Feb 11, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
A ratiometric iron probe enables investigation of iron distribution within tumour spheroids
Isaac J Carney1, Jacek L Kolanowski1, Zelong Lim1
1School of Chemistry, The University of Sydney, NSW 2006, Australia. elizabeth.new@sydney.edu.au.
Abstract:
Iron dysregulation is implicated in numerous diseases, and iron homeostasis is profoundly influenced by the labile iron pool (LIP). Tools to easily observe changes in the LIP are limited, with calcein AM-based assays most widely used. We describe here FlCFe1, a ratiometric analogue of calcein AM, which also provides the capacity for imaging iron in 3D cell models.
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