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Infantile glaucoma in Down's syndrome (trisomy 21)
E I Traboulsi1, E Levine, M B Mets
1Center for Sight, Georgetown University Medical Center, Washington, D.C. 20007.
American Journal of Ophthalmology
|April 15, 1988
Summary
Infantile glaucoma in Down
Area of Science:
- Ophthalmology
- Genetics
- Pediatrics
Background:
- Down's syndrome (trisomy 21) is associated with various congenital anomalies.
- Infantile glaucoma is a rare but serious condition requiring early diagnosis and intervention.
Observation:
- Five patients with Down's syndrome and bilateral infantile glaucoma were studied.
- Four presented in infancy with corneal clouding, elevated intraocular pressure, and photophobia.
- One case was diagnosed late due to nasolacrimal duct obstruction.
Findings:
- Two patients developed cataracts and retinal detachment, necessitating multiple surgeries.
- The combination of congenital glaucoma, severe myopia, and cataracts in trisomy 21 increases risk for poor visual outcomes.
- Retinal detachment is a significant complication in this cohort.
Implications:
- Early screening for infantile glaucoma in infants with Down's syndrome is crucial.
- Comprehensive ophthalmological management is vital for patients with trisomy 21 and glaucoma.
- Understanding these associations can improve long-term visual prognosis in affected children.