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Related Experiment Video

Updated: Feb 11, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Rectal cancer and the pathologist.

Mariana Berho¹, Pablo A Bejarano²

¹Department of Pathology, Cleveland Clinic Florida, Weston, FL, USA - berhom@ccf.org.

Minerva Chirurgica

|April 17, 2018

Summary

This summary is machine-generated.

Pathologists play a crucial role in rectal cancer care by evaluating surgical specimens for prognostic factors. Their meticulous examination aids in accurate staging and informs treatment decisions for rectal adenocarcinoma.

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Area of Science:

Pathology
Surgical Oncology
Gastroenterology

Background:

Rectal carcinoma management relies heavily on pathological examination of surgical specimens.
Key prognostic indicators are assessed through gross and microscopic evaluation.

Purpose of the Study:

To outline the essential role of pathologists in evaluating rectal carcinoma specimens.
To detail the critical features pathologists assess for prognostic and therapeutic implications.

Main Methods:

Review of literature and authors' experience in handling rectal specimens.
Evaluation of margins, mesorectal quality, lymph node sampling, tumor budding, response to therapy, and vascular/perineural invasion.
Selection of tumor sections for molecular testing.

Main Results:

Pathological assessment of margins and mesorectal completeness indicates surgical quality.
Lymph node yield depends on pathologist diligence; grading of tumor budding and response to therapy are established.
Vascular invasion location and molecular markers provide prognostic information.

Conclusions:

Meticulous pathological evaluation of rectal carcinoma specimens is vital for accurate staging and prognosis.
Pathologists provide critical information for patient management, from initial diagnosis to treatment planning and surgical quality assessment.