Comparing the Influence of Five Patch Types on the Result of a 12-Day Cumulative Irritancy Patch Test

A 12-day cumulative irritancy patch test is available for predicting skin irritation potential. This study is important to determine the ideal patch type to be used in the irritancy patch test. This study was conducted to determine the cumulative skin irritation potential of five different patch types using predictive patch test techniques. Five types of patches were tested in a 12 day repeated insult test. The patch types were Hill Top Chamber occlusive, Finn Chamber occlusive, Band-Aid semiocclusive, Webril^® semiocclusive, and Webril^® occlusive. The test materials applied to the patches were cream, lotion, 2% bath cream, and controls of 1% sodium lauryl sulfate (1% SLS), respectively. A dermatologist performed the grading. The test results revealed that with cream, the cumulative scores of Hill Top Chamber occlusive, Finn Chamber occlusive, Band-Aid semiocclusive, Webril^® semiocclusive, and Webril^® occlusive were 22, 27, 16, 9, and 21, respectively; with lotion, the cumulative scores were 192, 200, 192, 200, and 70, respectively; with 2% bath cream, the cumulative scores were 523, 306, 523, 306, and 506, respectively; with 1% sodium dodecyl sulfate solution, the cumulative scores were 792, 801, 753, 526, and 841, respectively. Comparison of the five different patch types revealed that Webril^® semiocclusive had the lowest cumulative irritation scores and incidence of adverse reactions. Comparison of the three test materials revealed that cream was the mildest material with the lowest cumulative irritation scores.