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Subclinical vestibular dysfunction in migraineurs without vertigo: A Clinical study
L Bernetti1, C Pellegrino2, I Corbelli1
1Department of Medicine, Neurologic Clinic, Headache Centre, University of Perugia, Perugia, Italy.
Acta Neurologica Scandinavica
|April 17, 2018
Summary
Migraine patients without vertigo show subclinical vestibular dysfunction. Vestibular-cerebellar dysfunction is suggested in migraineurs, especially those with aura.
Area of Science:
- Neurology
- Ophthalmology
- Oto-rhino-laryngology
Background:
- Migraine is a complex neurological disorder.
- Vestibular system dysfunction is increasingly recognized in migraineurs.
- Subclinical vestibular alterations may precede overt symptoms.
Purpose of the Study:
- To investigate subclinical vestibular dysfunction in migraine patients without a history of vertigo.
- To compare vestibular function between migraineurs and healthy controls.
Main Methods:
- Observational study comparing episodic migraineurs (with/without aura) and healthy controls.
- Comprehensive vestibular examination including Pagnini-McClure's, Dix-Hallpike's, video head impulse test (V-HIT), and caloric vestibular stimulation.
- Analysis of nystagmus and slow-phase angular velocity using video-nystagmography.
Main Results:
- Migraineurs exhibited statistically higher angular velocity (AV) in caloric vestibular stimulation tests compared to controls.
- Migraineurs showed significantly higher V-HIT results, indicating enhanced vestibulo-ocular reflex gain.
- No demographic differences were observed between migraineurs and controls.
Conclusions:
- Migraineurs without prior vertigo or dizziness demonstrate subclinical vestibular pathway alterations.
- Findings support a vestibular-cerebellar dysfunction hypothesis in migraine, particularly in those with aura.
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