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Updated: Feb 11, 2026

Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli
Published on: August 13, 2016
Circular-shaped microfluidic device to study the effect of shear stress on cellular orientation
Da Yeon Park1, Tae Hyeon Kim2, Jong Min Lee2
1Department of Biomedical Engineering, Sogang University, Seoul, Korea.
Abstract:
Understanding the effects of shear stress on mammalian cells is a crucial factor for understanding a number of biological processes and diseases. Here, we show the development of a circular-shaped microfluidic device for the facile generation of shear stress gradients. With this microfluidic device, the effect of shear stress on orientation of human umbilical vein endothelial cells was studied. This microfluidic device, which enables to control the alignment of human umbilical vein endothelial cells within a microchannel, can be a valuable tool to mimic blood vessels.
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