Recent advances in ultrasound-triggered therapy

Area of Science:

• Biomedical Engineering
• Medical Imaging
• Pharmacology

Background:

• Ultrasound is a non-invasive, real-time diagnostic tool with emerging therapeutic applications.
• Advancements in ultrasound technology and ultrasound contrast agents (UCAs) facilitate targeted treatment strategies.
• Spatiotemporal control of ultrasound enables site-specific delivery of therapeutic agents, minimizing side effects.

Purpose of the Study:

• To review the mechanisms of ultrasound-mediated targeted therapy.
• To summarize current applications of ultrasound-mediated targeted therapy across diverse medical fields.
• To discuss challenges and future prospects for clinical implementation.

Main Methods:

• Literature review of ultrasound-mediated targeted therapy.
• Analysis of mechanisms, applications, and challenges.
• Focus on therapeutic delivery and modulation.

Main Results:

• Ultrasound with or without UCAs allows for precise, controllable therapeutic agent delivery.
• Applications span oncology, cardiovascular diseases, central nervous system disorders, musculoskeletal conditions, and stem cell therapy.
• The technique shows promise for site-specific treatment with reduced systemic side effects.

Conclusions:

• Ultrasound-mediated targeted therapy offers a promising approach for various clinical applications.
• Further research is needed to address ongoing challenges for broader clinical adoption.
• Continued development is crucial for optimizing ultrasound-based therapeutic strategies.