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Updated: Feb 11, 2026
Viral Nanoparticles for In vivo Tumor Imaging
Published on: November 16, 2012
Synthesis, characterization, radiolabeling and biodistribution of a novel cyclohexane dioxime derivative as a
M A Motaleb1, Adli A Selim1, M El-Tawoosy1
1a Labeled Compounds Department , Hot Laboratories Center, Atomic Energy Authority , Cairo , Egypt.
Purpose:
Dioxime derivative is reported to exhibit high affinity towards tumor cells. The objective of the present study is to synthesize a new dioxime derivative to be labeled with technetium-99m for using as a solid tumor marker.
Materials And Methods:
((2E,2',3E,3')-3,3'-(cyclohexane-1,2-diylbis (azanylylidene)) bis-(butan-2-one)dioxime) was synthesized by condensation of Butan-2,3-dione monooxime and diaminocyclohexane and labeled with 99mTc. The in-vivo distribution of the agent was studied by carrying out biodistribution in tumor bearing Albino mice.
Results:
A new cyclohexane dioxime derivative was synthesized with a good yield of 93 ± 2% and its complexation with 99mTc was prepared with 85 ± 4% radiochemical yield under the optimized conditions and the preparation exhibited in-vitro stability up to 6 h. Biodistribution studies showed high uptake in tumor cells with T/NT (target to non-target ratio) = 3.4 ± 0.2 after 0.5 h post injection.
Conclusion:
As a result of biodistribution studies, the newly synthesized cyclohexane dioxime derivative showed its good uptake in tumor cells, which affords a potential radiopharmaceutical that could be used as a good tumor imaging agent.
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