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Published on: November 11, 2014
Intravenous Immunoglobulin and Methylprednisolone for Clozapine-Associated Perimyocarditis
Albert Cheng1, Mohanned Ahmed, Waqas Shuaib
1Wichita Falls Family Practice Residency Program, Wichita Falls, TX.
Clinical Features:
Cardiotoxicity is a rare but serious side effect of clozapine. We present a case of a psychiatric patient on chronic clozapine 75 mg daily, who presented with congestive heart failure secondary to the cardiotoxic effects of the psychiatric medication.
Therapeutic Challenge:
Conventional heart failure treatment failed to improve symptoms.
Solution:
A course of 40 mg of intravenous immunoglobulin and 125 mg of steroids was implemented, after which the patient made a full recovery. We hope to raise awareness of concurrent clozapine-induced pericarditis and myocarditis and propose a role of intravenous immunoglobulin and steroids in the treatment of drug-induced cardiomyopathy.
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