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Related Experiment Video

Updated: Feb 11, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
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Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy.

Eugene Shostak1,2, Lida P Hariri1,2,3,4, George Z Cheng1,2

  • 1Division of Pulmonary and Critical Care.

Journal of Bronchology & Interventional Pulmonology
|April 17, 2018
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Summary
This summary is machine-generated.

Needle-based optical coherence tomography (OCT) visualizes lymph node microstructures, potentially improving lung cancer staging accuracy by guiding transbronchial needle aspiration (TBNA) and reducing sampling errors.

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Area of Science:

  • Pulmonary Medicine
  • Oncology
  • Medical Imaging

Background:

  • Transbronchial needle aspiration (TBNA) is crucial for lung cancer staging but prone to sampling errors.
  • Endobronchial ultrasound (EBUS) aids TBNA, yet sampling inaccuracies persist.
  • Optical coherence tomography (OCT) offers high-resolution, real-time imaging.

Purpose of the Study:

  • To assess if needle-based OCT can provide microstructural lymph node information.
  • To determine if OCT guidance can improve TBNA accuracy and reduce sampling errors.

Main Methods:

  • Ex vivo needle-based OCT imaging was performed on 26 human thoracic lymph nodes.
  • OCT findings were compared with matched histology for accuracy.
  • OCT's ability to differentiate lymph node structures and malignancy was evaluated.

Main Results:

  • OCT successfully visualized key lymph node microstructures like follicles, adipose tissue, and blood vessels.
  • Malignant carcinoma in lymph nodes exhibited distinct OCT features correlating with subtype morphology.
  • OCT differentiated lymph node tissue from adjacent airway walls.

Conclusions:

  • OCT provides detailed microstructural data valuable for guiding TBNA lymph node sampling.
  • OCT can complement EBUS in thoracic lymph node assessment.
  • Further in vivo studies are warranted to confirm OCT's clinical utility.