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Effects of diphosphonate and x-rays on bone lesions induced in rats by prostate cancer cells
M Pollard1, P H Luckert, J Scheu
1Lobund Laboratory, University of Notre Dame, IN.
Cancer
|May 15, 1988
Abstract:
Prostate adenocarcinoma-III (PA-III) cells deposited over the scapula of Lobund-Wistar (L-W) rats induced osteolytic and osteoplastic changes in that bone. The osteolytic process was prevented and interrupted by administrations of dichloromethylene diphosphonate (Cl2MDP); but the osteoplastic process, once initiated, continued. The latter process was interrupted by ionizing radiation. Treatments of PA-III-affected bones with Cl2MDP and x-rays immobilized both osteolytic and osteoplastic processes.