Related Experiment Video
Updated: Feb 11, 2026
11:15
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.7K
Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia
Rosa C Paolicelli1, Giorgio Bergamini2, Lawrence Rajendran1
1Systems and Cell Biology of Neurodegeneration, IREM - Institute for Regenerative Medicine, University of Zurich, Switzerland.
Neuroscience
|April 17, 2018
Summary
Extracellular vesicles (EVs) from microglia play a key role in brain communication. This review explores their function and involvement in Alzheimer's disease.
Area of Science:
- Neuroscience
- Cell Biology
- Biochemistry
Background:
- Extracellular vesicles (EVs), including exosomes and microvesicles, are released from nearly all cell types.
- EVs mediate intercellular communication by transferring lipids, proteins, and RNAs.
- In the central nervous system, EVs facilitate communication between neurons and glia, such as microglia.
Purpose of the Study:
- To review the biogenesis and function of microglia-derived EVs.
- To explore the role of microglia-related EVs in Alzheimer's disease pathology.
Main Methods:
- Literature review of recent studies on extracellular vesicles.
- Focus on microglia-related EVs and their functions.
- Analysis of EV involvement in neuroinflammation and Alzheimer's disease.
Main Results:
- Extracellular vesicles are crucial for extensive cross-talk among neurons, astrocytes, and microglia.
- Microglia-derived EVs contribute to intercellular communication in both healthy and diseased brains.
- Evidence suggests a significant role for these EVs in Alzheimer's disease.
Conclusions:
- Microglia-derived extracellular vesicles are vital mediators of neural communication.
- Understanding their function is critical for elucidating Alzheimer's disease mechanisms.
- Further research into microglia EVs may offer therapeutic insights for neurodegenerative diseases.
Related Concept Videos
01:23Techniques of Therapeutic Communication II: Focusing, Paraphrasing, and Summarizing
11.7K
Focusing involves centering a conversation on a message's critical elements or concepts. Focusing is valuable if the talk is vague or patients begin to repeat themselves. Sometimes, when patients are asked about their symptoms, they may go off-topic and try to tell their entire life story. Respectfully, the nurse should bring the conversation back into focus.
This therapeutic technique can also be used when a patient brings up pertinent information during a health-related conversation. The...
This therapeutic technique can also be used when a patient brings up pertinent information during a health-related conversation. The...
11.7K
01:03Communication
8.8K
Communication between two animals occurs when one animal transmits an information signal that causes a change in the animal that receives the information. Organisms communicate with one another in a host of different ways. Signals can be auditory, chemical, visual, tactile, or a combination of these. Communication is a critical behavioral adaptation that promotes survival, growth, and reproduction.
8.8K
01:28Communication
11.5K
Sharing information, concepts, and emotions to foster mutual understanding is communication. The sender, recipient, and transaction must be considered in this manner. The sender is the person who shares the message, the recipient is the person who receives and understands the message, and the transaction is the method used to deliver the message and the variables that affect the communication's context and surroundings. The nurse-client connection is built on therapeutic communication.
11.5K
01:42The Extracellular Matrix
89.4K
Overview
89.4K
02:03What is Cell Signaling?
131.1K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
131.1K
01:28Neuronal Communication
3.5K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
3.5K