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White-matter functional networks changes in patients with schizophrenia
Yuchao Jiang1, Cheng Luo1, Xuan Li1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Neuroimage
|April 17, 2018
Summary
Resting-state functional MRI reveals altered white-matter network connectivity in schizophrenia patients, showing decreased perception-motor network function and compensatory changes in deeper networks.
Area of Science:
- Neuroscience
- Neuropsychiatry
- Brain Imaging
Background:
- Resting-state functional MRI (rsfMRI) primarily studies gray matter connectivity.
- Schizophrenia is linked to white matter abnormalities, but rsfMRI's role in white matter dysfunction is unclear.
- Previous research focused on structural white matter changes, not functional connectivity.
Purpose of the Study:
- To investigate white-matter functional connectivity using rsfMRI in schizophrenia patients.
- To identify and characterize large-scale white-matter networks.
- To examine interactions between white-matter and gray-matter networks in schizophrenia.
Main Methods:
- rsfMRI data from 97 schizophrenia patients and 126 healthy controls.
- Voxel-based cluster analysis to identify 10 white-matter networks.
- Analysis of low-frequency oscillation amplitudes and inter-network functional connectivity.
Main Results:
- Schizophrenia patients exhibited decreased low-frequency oscillation amplitudes in white-matter networks.
- Increased functional connectivity was observed in superficial perception-motor white-matter networks in patients.
- Decreased connectivity between superficial white-matter and gray-matter perception-motor networks was found, with compensatory increases in middle/deep white-matter networks.
Conclusions:
- Schizophrenia involves disrupted functional connectivity within and between white-matter and gray-matter networks.
- Altered perception-motor network interactions in schizophrenia may involve compensatory mechanisms.
- These findings highlight the potential of rsfMRI for understanding white matter dysfunction in schizophrenia.
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