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Viscometer validation studies for routine and experimental hemorheological measurements.

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Clinical Hemorheology and Microcirculation
|April 18, 2018
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Summary

Accurate blood viscosity measurement requires careful validation. Comparing viscometers revealed differences, and sample storage at 37°C significantly altered whole blood viscosity (WBV) over time.

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Area of Science:

  • Biomedical Engineering
  • Rheology
  • Hematology

Background:

  • Blood viscosity measurement presents challenges due to intrinsic blood properties and viscometer artifacts.
  • Standardization is crucial for reliable rheological data in clinical and research settings.

Purpose of the Study:

  • To identify potential issues with a cone-plate viscometer (Brookfield DV-III Ultra LV) prior to use.
  • To compare its performance against a capillary viscometer (Hemorex Hevimet 40).
  • To assess the impact of sample storage conditions and thermal calibration on viscosity measurements.

Main Methods:

  • Intra-observer variability assessed through replicate measurements of blood samples.
  • Comparison of cone-plate and capillary viscometers using multiple blood samples.
  • Evaluation of sample storage effects at different temperatures (4°C, 22°C, 37°C) up to 48 hours.
  • Assessment of thermal calibration impact by measuring samples at varied temperatures.

Main Results:

  • Low intra-observer variability (<5% CV) was observed for both viscometers.
  • Average differences of 7% in whole blood viscosity (WBV) and 10% in plasma viscosity (PV) were noted between instruments.
  • WBV significantly decreased after 3 hours at 37°C (p<0.05) at shear rates of 50 and 100 s-1.
  • WBV at higher shear rates and PV remained stable across temperatures; thermal calibration did not significantly affect measurements.

Conclusions:

  • Rigorous validation of viscometers and measurement protocols is essential before routine or experimental use.
  • Understanding the influence of storage conditions and instrument type is critical for accurate blood viscosity assessment.