Liver Transplantation Using Prolonged Cold Ischemia Time Grafts Preserved With Institute George-Lopez-1 Solution

Area of Science:

• Hepatology
• Transplantation Surgery
• Organ Preservation

Background:

• The University of Wisconsin solution is a standard preservation fluid for liver transplantation.
• Institute George-Lopez-1 (IGL-1) solution offers lower potassium and viscosity compared to the University of Wisconsin solution.
• Evaluating IGL-1 solution's efficacy with varying cold ischemia times is crucial for optimizing liver graft outcomes.

Purpose of the Study:

• To compare the outcomes of liver grafts preserved in IGL-1 cold storage solution based on cold ischemia times (CITs) greater than or less than 8 hours.
• To assess the safety and effectiveness of IGL-1 solution in liver transplantation.
• To analyze early graft function and 1-year patient survival rates in relation to CIT.

Main Methods:

• Retrospective analysis of 252 liver transplantations performed between January 2014 and December 2016.
• Patients were divided into two groups: Group I (CIT < 8 hours, N=155) and Group II (CIT > 8 hours, N=97).
• Comparison of donor characteristics, laboratory data (AST, ALT, bilirubin), and 1-year patient survival rates between the two groups.

Main Results:

• No significant differences were observed in donor characteristics or indications for liver transplantation between the groups.
• The only significant difference in laboratory data was aspartate aminotransferase levels on day 1 post-transplantation.
• Similar 1-year patient survival rates were observed: 85.88% for Group I and 85.75% for Group II.
• Early graft function and post-transplantation liver function tests at day 7 showed no statistically significant differences between the groups.

Conclusions:

• IGL-1 solution is a safe and effective preservation solution for liver transplantation.
• Cold ischemia times exceeding 8 hours with IGL-1 solution did not negatively impact early graft function or 1-year patient survival.
• IGL-1 solution demonstrates good results in liver transplantation, offering flexibility in organ preservation duration.