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Donor-Derived Candida dubliniensis Resulting in Perigraft Abscesses in a Liver Transplant Recipient Proven by Whole

Y E Teh1, M L T Ang2, M V La3

  • 1Department of Infectious Diseases, Singapore General Hospital, Singapore.

Transplantation Proceedings
|April 18, 2018
PubMed
Abstract

Insights

Fungal transmission during organ transplant was confirmed using whole genome sequencing. A donor

Area of Science:

  • Transplantation immunology
  • Medical mycology
  • Genomics

Background:

  • Fungal transmission through organ transplantation is a recognized risk, but molecular evidence is often lacking.
  • This case investigates donor-derived fungal infection in a liver transplant recipient.

Observation:

  • Candida dubliniensis was isolated from the donor's bronchus and the recipient's abscesses.
  • Whole genome sequencing confirmed the genetic relatedness of the fungal isolates.
  • The infection was likely transmitted via a contaminated segment of the inferior vena cava.

Findings:

  • Donor-derived Candida dubliniensis infection in a liver transplant recipient.
  • Molecular confirmation of fungal transmission via organ procurement.
  • Successful treatment of candidiasis in the recipient post-transplant.

Implications:

  • Highlights the critical need for stringent sterile techniques during multi-organ procurement.
  • Emphasizes the potential for fungal contamination in sequential organ explantation.
  • Underscores the value of whole genome sequencing in verifying transplant-associated infections.

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