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Overexpression of Lox in triple-negative breast cancer

Cornelia Leo1, Christine Cotic2, Victoria Pomp3

  • 1Department of Gynecology, Kantonsspital Baden, Baden, Switzerland.

Annals of Diagnostic Pathology
|April 18, 2018
PubMed
Abstract

Insights

Lysyl oxidase (Lox) is overexpressed in triple-negative breast cancer (TNBC), a subtype lacking targeted therapies. This finding suggests Lox may be a potential therapeutic target for TNBC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Triple-negative breast cancer (TNBC) comprises 15% of breast cancers, characterized by poor prognosis and early metastasis.
  • TNBC lacks established therapeutic targets due to negative estrogen receptor, progesterone receptor, and Her2 statuses.
  • Epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis.

Purpose of the Study:

  • To investigate the expression patterns of EMT markers Snail, Twist-1, and Lox in TNBC and non-TNBC subtypes.
  • To correlate the expression of these markers with clinico-pathological parameters and patient prognosis.

Main Methods:

  • Analysis of 659 breast cancer samples from tissue microarrays, categorized into TNBC (n=146) and non-TNBC (n=513) groups.
  • Semi-quantitative immunohistochemical analysis of Snail, Twist-1, and Lox expression using a three-tiered scoring system.
  • Statistical correlation of marker expression with clinico-pathological data and overall survival.

Main Results:

  • Strong Lox overexpression was significantly higher in TNBC compared to non-TNBC (p < 0.001).
  • No significant difference in Snail or Twist-1 expression was observed between TNBC and non-TNBC groups (p > 0.05).
  • Lox expression was significantly stronger in poorly differentiated (G3) breast cancers (p < 0.001).

Conclusions:

  • The EMT marker Lox exhibits differential expression in breast cancer, with significant overexpression in TNBC.
  • While Lox expression was not linked to prognosis in this study, it warrants further investigation as a potential therapeutic target for TNBC.
  • This research highlights Lox as a promising candidate for future systemic therapy development in TNBC.
Keywords:
Breast cancerEpithelial-mesenchymal transitionIntrinsic subtypes

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