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Updated: Feb 11, 2026

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
Published on: June 23, 2023
Body mass index, sitting time, and risk of Parkinson disease
Elin Roos1, Alessandra Grotta1, Fei Yang1
1From the Department of Medicine (E.R., Y.T.L.), Unit of Clinical Epidemiology, Karolinska Institutet, T2, Stockholm; Department of Medical Epidemiology and Biostatistics (A.G., F.Y., R.B., W.Y., H.-O.A., K.W.), and Department of Clinical Neuroscience (K.W.), Karolinska Institutet, Stockholm; Centre for Health Equity Studies (A.G.), Stockholm University/Karolinska Institutet, Stockholm, Sweden; Department of Statistics and Quantitative Methods (R.B.), University of Milano-Bicocca, Milan, Italy; Clinical Effectiveness Research Group (H.-O.A.), Institute of Health and Society, University of Oslo, Norway; and Department of Medicine (Y.T.L.), Clinic of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
Objective:
Causes of Parkinson disease are largely unknown, but recent evidence suggests associations with physical activity and anthropometric measures.
Methods:
We prospectively analyzed a cohort of 41,638 Swedish men and women by detailed assessment of lifestyle factors at baseline in 1997. Complete follow-up until 2010 was achieved through linkage to population-based registers. We used multivariable Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals (CIs).
Results:
We identified 286 incident cases of Parkinson disease during follow-up. Multivariable adjusted hazard ratios were 1.06 (95% CI 0.76-1.47) for sitting time ≥6 vs <6 hours per day; and 1.13 (95% CI 0.60-2.12) for body mass index ≥30 vs <25 kg/m2. Results did not differ by sex.
Conclusions:
No association between prolonged sitting time per day or obesity and risk of Parkinson disease was found.
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