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Cigarette Smoking and Incident Heart Failure: Insights From the Jackson Heart Study

Daisuke Kamimura1, Loretta R Cain2, Robert J Mentz3

  • 1Department of Medicine (D.K., E.R.F., J.B., M.D.W., A.C., M.E.H.).

Circulation
|April 18, 2018
PubMed

Insights

Cigarette smoking significantly impacts heart health, leading to left ventricular (LV) changes and increasing the risk of heart failure (HF) hospitalization in Black adults. This study highlights smoking as a key risk factor for cardiac dysfunction.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Cigarette smoking is a known contributor to cardiovascular disease.
  • Previous research suggests links between smoking and cardiac dysfunction.
  • The Jackson Heart Study investigated cardiovascular health in Black adults.

Purpose of the Study:

  • To examine the association between cigarette smoking and left ventricular (LV) structure and function.
  • To investigate the relationship between smoking and brain natriuretic peptide levels.
  • To determine if smoking is associated with incident heart failure (HF) hospitalization.

Main Methods:

  • Analysis of 4129 Black participants from the Jackson Heart Study (never, current, former smokers).
  • Cardiac magnetic resonance imaging used to assess LV structure and function in 1092 participants.
  • Brain natriuretic peptide levels and incident HF hospitalizations analyzed in subgroups.

Main Results:

  • Current smoking linked to increased LV mass index and reduced LV circumferential strain.
  • Smoking status, intensity, and burden correlated with higher brain natriuretic peptide levels.
  • Current smoking, smoking intensity, and smoking burden significantly increased HF hospitalization risk.

Conclusions:

  • Cigarette smoking is a significant risk factor for LV hypertrophy and systolic dysfunction in Black individuals.
  • Smoking independently predicts incident heart failure hospitalization, even after accounting for coronary heart disease.
  • Public health interventions targeting smoking cessation are crucial for cardiovascular health in this population.
Abstract

Keywords:
African Continental Ancestry Groupcardiac imaging techniquescoronary diseaseheart failuresmoking

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