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Review of the Latest Percutaneous Devices in Critical Limb Ischemia

Leila Haghighat1, Sophia Elissa Altin2, Robert R Attaran3

  • 1Department of Internal Medicine, Yale-New Haven Hospital, New Haven, CT 06520 USA. leila.haghighat@yale.edu.

Journal of Clinical Medicine
|April 18, 2018
PubMed

Insights

Critical limb ischemia (CLI) management has advanced with endovascular interventions. This review covers percutaneous devices and techniques for CLI, including angioplasty, stents, and cell therapies, to prevent amputation.

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Peripheral Arterial Disease

Background:

  • Critical limb ischemia (CLI) is an advanced stage of peripheral arterial disease.
  • CLI can lead to amputation or death without intervention.
  • Endovascular interventions are now a primary treatment for CLI.

Purpose of the Study:

  • To review current endovascular devices and techniques for CLI management.
  • To summarize supporting data for these interventions.
  • To discuss ongoing clinical trials in CLI treatment.

Main Methods:

  • Review of percutaneous devices for vessel patency (angioplasty, drug-coated balloons, stents, scaffolds, atherectomy).
  • Inclusion of embolic protection devices and cell-based therapies.
  • Discussion of current and future clinical trials.

Main Results:

  • Endovascular techniques have significantly advanced CLI treatment over the last decade.
  • A range of devices are available to establish and maintain vessel patency.
  • Embolic protection and cell therapies are also key components of CLI management.

Conclusions:

  • Endovascular interventions are crucial for managing CLI and preventing amputation.
  • The field continues to evolve with new devices and therapies.
  • Ongoing trials will further shape the future of CLI treatment.

Keywords:
atherectomybare metal stentscritical limb ischemiacryoplastydrug-coated balloonsdrug-eluting stentsembolic protection devicespercutaneous transluminal angioplastyperipheral artery disease

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