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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
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Metabolic Features of Multiple Myeloma
Chaima El Arfani1, Kim De Veirman2, Ken Maes3
1Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium. Chaima.El.Arfani@vub.be.
International Journal of Molecular Sciences
|April 18, 2018
Summary
Multiple myeloma cells exhibit altered glucose and glutamine metabolism, impacting drug resistance. These metabolic shifts in cancer cells are influenced by the bone marrow microenvironment and affect cell proliferation and survival.
Area of Science:
- Oncology
- Cancer Metabolism
- Molecular Biology
Background:
- Multiple myeloma (MM) is characterized by malignant plasma cell accumulation in the bone marrow.
- Cancer cells, including those in MM, undergo significant metabolic rearrangements to support tumor growth and proliferation.
- The bone marrow microenvironment may influence these metabolic adaptations in MM cells.
Purpose of the Study:
- To review the critical changes in glucose and glutamine metabolism in multiple myeloma.
- To explore the link between these metabolic alterations and the development of drug resistance in MM.
- To understand how metabolites influence cancer development by affecting metabolic pathways and transcription factors.
Main Methods:
- Literature review focusing on metabolic shifts in multiple myeloma.
- Analysis of studies investigating glucose and glutamine metabolism in cancer.
- Examination of the role of metabolites and enzymes in drug resistance and cellular regulation.
Main Results:
- MM cells show enhanced glycolysis and glutaminolysis compared to normal cells.
- Metabolite and enzyme levels are frequently altered (upregulated or downregulated) in MM.
- These metabolic changes are implicated in the emergence of drug resistance and influence proliferation and apoptosis.
Conclusions:
- Altered glucose and glutamine metabolism are key features of multiple myeloma.
- Metabolic reprogramming in MM cells contributes to therapeutic resistance.
- Metabolites play a dual role, supporting cancer progression and interfering with regulatory pathways.
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