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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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Induction of Experimental Autoimmune Hypophysitis in SJL Mice
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Autoimmune Hypophysitis Presenting as Solid-Cystic Mass Managed Conservatively.

Manash P Baruah1, Anuradha Singh2, Nirod Medhi3

  • 1Department of Endocrinology, Excel Centre, Guwahati, Asam, India.

Polish Journal of Radiology
|April 18, 2018
PubMed
Summary
This summary is machine-generated.

Autoimmune hypophysitis (AH) can present as a solid-cystic pituitary mass. Conservative treatment with steroids may be effective, especially when surgery is not urgently indicated.

Area of Science:

  • Endocrinology
  • Neuroimaging
  • Immunology

Background:

  • Autoimmune hypophysitis (AH) is a rare inflammatory pituitary condition affecting women of reproductive age.
Keywords:
AnteriorAutoimmune DiseasesPituitary DiseasesPituitary Gland

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  • It often causes pituitary dysfunction and can lead to compressive symptoms due to gland enlargement.
  • Surgical resection, if needed, results in iatrogenic hypopituitarism requiring lifelong hormone replacement.