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Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit
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Genetically enhanced T lymphocytes and the intensive care unit
Tiberiu Tat1,2, Huming Li3, Catalin-Sorin Constantinescu1,4
1Intensive Care Unit, Ion Chiricuta Clinical Cancer Research, Cluj Napoca, Romania.
Oncotarget
|April 18, 2018
Summary
Chimeric antigen receptor-modified T cells (CAR-T) and donor lymphocyte infusion (DLI) are advanced immunotherapies. This review examines their efficacy, toxicity, and treatment in intensive care unit patients.
Area of Science:
- Immunology
- Oncology
- Cellular Therapy
Background:
- Chimeric antigen receptor-modified T cells (CAR-T) are genetically engineered lymphocytes for cancer immunotherapy.
- Donor lymphocyte infusion (DLI) is an adoptive therapy used post-hematopoietic stem cell transplant for anti-tumor and anti-infectious effects.
Purpose of the Study:
- To review the current research status of CAR-T cells and DLI in intensive care unit (ICU) patients.
- To analyze the efficacy, toxicity, side effects, and treatment strategies for these therapies in the ICU setting.
Main Methods:
- Literature review of CAR-T cell and DLI research.
- Analysis of clinical data regarding efficacy and adverse events in ICU patients.
Main Results:
- CAR-T cells represent a novel immunotherapy for hematological malignancies.
- DLI offers anti-tumor and anti-infectious benefits after stem cell transplantation.
Conclusions:
- CAR-T cells and DLI are significant advancements in lymphocyte engineering and immunotherapy.
- Further research is needed to optimize the use and management of these therapies in critically ill patients.
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