Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

62.4K
Overview
62.4K
Bone Structure01:55

Bone Structure

51.9K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.9K
Bone Remodeling01:40

Bone Remodeling

40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
Compact Bone01:27

Compact Bone

16.8K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.8K
Bone Disorders01:29

Bone Disorders

5.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.5K
The Hyoid Bone01:12

The Hyoid Bone

5.2K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

Journal of nanobiotechnology·2021
Same author

Comparative Evaluation of Microbiota Dynamics and Metabolites Correlation Between Spontaneous and Inoculated Fermentations of Nanfeng Tangerine Wine.

Frontiers in microbiology·2021
Same author

Calcium phosphate-based composite cement: Impact of starch type and starch pregelatinization on its physicochemical properties and performance in the vertebral fracture surgical models in vitro.

Journal of biomedical materials research. Part B, Applied biomaterials·2021
Same author

Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis.

Cell death & disease·2021
Same author

Author Correction: Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery.

Nature communications·2021
Same author

Ultra-Conformable Ionic Skin with Multi-Modal Sensing, Broad-Spectrum Antimicrobial and Regenerative Capabilities for Smart and Expedited Wound Care.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2021
Same journal

Long-term evaluation of plasma electrolytic oxidation (PEO) surface-modified WE43MEO magnesium alloy screws and plates reveals safe and controlled degradation in a 18-month minipig model.

Journal of orthopaedic translation·2026
Same journal

Corrigendum to 'Author's reply to the letter regarding "CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis"' [J Orthop Transl 2026 Mar 26;57:101087].

Journal of orthopaedic translation·2026
Same journal

Semaglutide alleviates osteoarthritis independent of weight loss via GLP-1R-mediated activation of autophagy through AKT/mTOR inhibition.

Journal of orthopaedic translation·2026
Same journal

Therapeutic effect of mitochondrial transfer on bone tissue diseases: treatment strategy of mitochondrial transplantation and delivery technology.

Journal of orthopaedic translation·2026
Same journal

Histone H3K18 lactylation: An exercise-induced epigenetic mechanism that inhibits osteoclast activity and protects against osteoporosis.

Journal of orthopaedic translation·2026
Same journal

Corrigendum to 'Deer antler polypeptides promote osteogenesis for fracture healing via activating neurosensory PGE2/EP4/p-CREB axis' [J Orthop Translat 58 (2026) 1-15/101112].

Journal of orthopaedic translation·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

68.6K

Macrophages and bone inflammation.

Qiaoli Gu1, Huilin Yang1, Qin Shi1

  • 1Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.

Journal of Orthopaedic Translation
|April 18, 2018
PubMed
Summary
This summary is machine-generated.

Macrophages play a key role in bone diseases driven by inflammation. Understanding macrophage polarization and their interaction with bone cells offers new therapeutic strategies for bone loss.

Keywords:
bone metabolisminflammationmacrophage

More Related Videos

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

26.0K
Bone Marrow-derived Macrophage Production
07:06

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

75.4K

Related Experiment Videos

Last Updated: Feb 11, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

68.6K
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

26.0K
Bone Marrow-derived Macrophage Production
07:06

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

75.4K

Area of Science:

  • Immunology
  • Bone Biology
  • Cellular Biology

Background:

  • Bone metabolism is regulated by the immune system, with inflammation contributing to bone destruction in diseases like rheumatoid arthritis and fracture.
  • Macrophages are immune cells that polarize into M1 (proinflammatory) and M2 (anti-inflammatory) phenotypes, influencing cytokine production.
  • These macrophages and their cytokines are implicated in bone loss during inflammatory bone diseases.

Purpose of the Study:

  • To review the role of macrophages in inflammatory bone diseases.
  • To discuss recent findings on macrophage involvement in bone formation and repair.
  • To provide insights into novel therapeutic strategies for bone diseases.

Main Methods:

  • Literature review focusing on macrophage polarization and function in bone tissue.
  • Analysis of studies investigating macrophage-bone cell interactions.
  • Synthesis of current research on inflammation-induced bone loss and repair.

Main Results:

  • Macrophages are present in bone tissue and interact with bone cells, influencing bone remodeling.
  • Macrophage polarization (M1/M2) dictates the inflammatory response and cytokine profiles, impacting bone destruction or formation.
  • Dysregulation of macrophage activity contributes to pathological bone conditions.

Conclusions:

  • Macrophages are critical regulators of bone metabolism, particularly in inflammatory conditions.
  • Targeting macrophage polarization and their interactions with bone cells presents a promising therapeutic avenue for bone diseases.
  • Further research into macrophage biology in bone is essential for developing effective treatments for bone loss.