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Long Non-Coding RNAs in Vascular Inflammation.

Stefan Haemmig1, Viorel Simion1, Mark W Feinberg1

  • 1Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Frontiers in Cardiovascular Medicine
|April 18, 2018
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) regulate cardiovascular disease (CVD) processes. This review explores lncRNAs in vascular inflammation, highlighting their potential as novel biomarkers and therapeutic targets for CVD.

Keywords:
acute inflammationcardiovascular diseasechronic inflammationlncRNAsvascular inflammation

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Area of Science:

  • Molecular Biology
  • Genomics
  • Cardiovascular Research

Background:

  • The non-coding genome produces diverse RNAs, including long non-coding RNAs (lncRNAs).
  • lncRNAs are increasingly recognized as regulators of biological processes, notably in cardiovascular disease (CVD).
  • Vascular inflammation is a key factor in acute and chronic CVD, yet lncRNA roles are not fully understood.

Purpose of the Study:

  • To review lncRNAs implicated in pro- and anti-inflammatory processes in vascular inflammation.
  • To explore the potential of lncRNAs as biomarkers and therapeutic targets in CVD.

Main Methods:

  • Literature review of studies on lncRNAs and vascular inflammation.
  • Analysis of lncRNA involvement in gene expression and cell signaling pathways related to CVD.
  • Examination of cell- and tissue-specific expression patterns of lncRNAs.

Main Results:

  • A growing number of lncRNAs are identified as regulators in vascular inflammation.
  • lncRNAs exhibit cell- and tissue-specific expression, suggesting targeted roles.
  • Functional evaluation of lncRNAs in vascular inflammation is still limited.

Conclusions:

  • lncRNAs are critical regulators in vascular inflammation associated with CVD.
  • Understanding lncRNA mechanisms in vascular inflammation offers new pathophysiological insights.
  • lncRNAs represent promising candidates for novel RNA-based biomarkers and therapeutics in CVD.