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Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia

Mahmoud Mohammadi1, Touraj Farazmandfar1, Majid Shahbazi1

  • 1Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

International Journal of Reproductive Biomedicine
|April 18, 2018
PubMed

Insights

Preeclampsia risk is linked to specific human leukocyte antigen (HLA) gene variations, particularly HLA-DQB1*0602. The absence of this allele may increase susceptibility to preeclampsia in certain ethnic groups.

Area of Science:

  • Immunogenetics
  • Reproductive Medicine
  • Human Genetics

Background:

  • Preeclampsia is a pregnancy disorder with unknown causes, potentially involving genetic and environmental factors.
  • The Major Histocompatibility Complex (MHC) is crucial for immune tolerance during pregnancy.
  • Understanding genetic predispositions is key to addressing preeclampsia.

Purpose of the Study:

  • To investigate the association between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia.
  • To explore potential genetic risk factors for preeclampsia development.

Main Methods:

  • Genomic DNA was extracted from 181 preeclampsia cases and 228 controls.
  • Human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphisms were identified using the SSP-PCR method.
  • Statistical analysis (Chi-square test) was employed to compare allele and genotype frequencies between groups.

Main Results:

  • A significant association was found between preeclampsia and the Sistani ethnic group (p=0.031).
  • Significant associations were observed between preeclampsia and HLA-DQB1*0602 allele frequencies (p<0.001).
  • Specific genotypes (heterozygote +0102/-0602 and negative homozygote -0102/-0602) and HLA-DQB1*0602 allele were linked to preeclampsia in the Fars ethnic group.

Conclusions:

  • Immune incompatibility appears to play a role in preeclampsia predisposition.
  • The absence of the HLA-DQB1*0602 locus may represent a risk factor for developing preeclampsia.
  • Genetic factors, specifically HLA polymorphisms, are implicated in preeclampsia pathogenesis.
Abstract

Keywords:
GenotypingHLA-DQPreeclampsia

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