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Updated: Feb 11, 2026

Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods
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Insights into the effects of the endocannabinoid system in cancer: a review

Ana Isabel Fraguas-Sánchez1, Cristina Martín-Sabroso1, Ana Isabel Torres-Suárez1,2

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Complutense University of Madrid, Madrid, 28040, Spain.

British Journal of Pharmacology
|April 18, 2018
PubMed

Insights

The endocannabinoid system shows promise as a cancer therapeutic target. While cannabinoids can inhibit cancer growth, some may paradoxically promote it, requiring further research.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • The endocannabinoid system (ECS) is increasingly recognized for its clinical medicine applications.
  • The ECS plays a significant role in cancer, with altered expression linked to prognosis and disease outcome.
  • Aberrant ECS expression varies by cancer type, influencing tumor growth and progression.

Purpose of the Study:

  • To explore the therapeutic potential of the endocannabinoid system in oncology.
  • To investigate the dual role of cannabinoids in cancer progression.

Main Methods:

  • Review of existing literature on ECS expression in tumors.
  • Analysis of studies detailing cannabinoid effects on cancer cell proliferation, migration, invasion, and angiogenesis.
  • Examination of research on dose-dependent effects of cannabinoids on tumor growth.

Main Results:

  • Endocannabinoid system expression is altered in various tumors compared to healthy tissues.
  • Cannabinoids demonstrate anticancer activities, including inhibition of proliferation, migration, invasion, and angiogenesis.
  • Lower concentrations of certain cannabinoids may stimulate tumor proliferation and growth.

Conclusions:

  • The endocannabinoid system presents a promising new therapeutic target for cancer treatment.
  • Further research is necessary to fully elucidate the complex effects of cannabinoids on tumor progression and to establish optimal therapeutic strategies.

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